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Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. Rheumatoid arthritis RA is a systemic inflammatory arthritis impacting primarily joints and cardiac and skeletal muscle. Thus, the objective is to understand the distinct effects of RA on cardiac and skeletal muscle, and to therapeutically target these tissues through endurance-based exercise as a way to improve RA mortality and morbidity.
Importantly, there were morphological, gene expression, and functional improvements in both the skeletal muscle and cardiac myopathies with exercise.
These morphological, molecular, and functional alterations were mitigated with regular exercise, thus suggesting exercise as a potential therapeutic intervention to lessen disease activity in the joint and the peripheral tissues, including the heart and skeletal muscle.
Using exercise as a therapeutic against, the progression of RA is often avoided due to fear of worsening RA pathology. Although there have been recent advances in the treatment of rheumatoid arthritis RA , patients still suffer considerable morbidity and are at risk for increased mortality.