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In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Presenting author disclosures may be found within the abstracts. Asterisks in the author lists indicate presenter of the abstract at the annual meeting. PSPP is working with PsychoGenics to develop and validate preclinical models and endpoints to enable the screening and profiling of assets, including small molecules, biologics, natural products, and devices. Methods: The PSPP aims to screen and profile candidate therapeutics in a number of preclinical assays.
Assets are evaluated in a tiered manner, starting with in vitro functional assays to rule out opioid receptor activity and to assess in vitro abuse liability. In vivo pharmacokinetic studies are then used to measure plasma and brain exposures to guide the dose range and pretreatment times for the side effect profile, in vivo efficacy, and in vivo abuse liability studies.
All experiments are blinded, both sexes are included, group sizes are determined by power analysis, and data are reported in accordance with ARRIVE guidelines. This includes validation of models of nerve injury, chemotherapy-induced neuropathic pain, post-operative pain, pain associated with osteoarthritis, deep muscle pain, and migraine, as well as validation of existing endpoints, of evoked pain measures but more importantly, validating non-evoked endpoints for use in these models.