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Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. Further information and requests for resources and reagents should be directed to and will be fulfilled by the Lead Contact, Miguel Fribourg ude. Type I interferons IFN are pleiotropic cytokines with potent antiviral properties that also promote protective T cell and humoral immunity.
The type I interferon IFN system constitutes a family of cytokines that modulate both innate and adaptive immune responses by promoting an antiviral state in cells upon recognition of conserved viral and bacterial structures, and by eliciting inflammatory signals that activate dendritic cells and promote T and B cell effector functions Crouse et al. A key feature of the type I IFN system is its rapid induction and amplification through a well-described feed-forward loop which ensures a strong immune response is mounted, but that also needs to be tightly regulated to avoid tissue damage Hall and Rosen, In both instances, evidence suggests that induction of regulatory T Treg cells is responsible in part for the observed immunosuppressive effects.
Treg cells are essential modulators of central and peripheral tolerance. A reduction in Treg cell numbers or function is a hallmark of autoimmune disease in animal models Kim et al. The transcription factor forkhead box P3 Foxp3 is the master regulator of the Treg cells immunosuppressive program, and is responsible for Treg cell function and stability van Loosdregt and Coffer, In Treg cells, Foxp3 expression and function are regulated through multiple molecular mechanisms including Foxp3 dimerization Song et al.
Herein, we utilized a transplant model in which allograft survival is dependent on regulatory Treg cells Conde et al. Consistent with previously published results Yang et al. A Schematic of experimental design for B - L.
