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Email riccardo. I designed a prospective longitudinal study which aimed to describe the "natural" history of Diabetic Cardiomyopathy measuring the changes in the viscoelastic properties of the left ventricular wall, demonstrating the involvement of the ECM and identifying potential disease marker and a molecular player for DCM progression.
Meanwhile, I also investigated the pathways involved in diabetic end-organ damage, focusing on the role of the phosphodiesterase type 5 and its inhibitors PDE5i. By designing an experimental study using an animal model of DN I demonstrated the beneficial effects of PDE5i on renal hemodynamic and function, also defining the underlying molecular mechanisms involved. Pushed from the inconsistencies of the published data about the protective role of PDE5i for diabetic complications, I performed the first non-sponsored, randomized, double-blind controlled trial to investigate the sex differences of PDE5 inhibition in patients with DCM demonstrating that the daily administration tadalafil improves cardiac contraction and the low-grade inflammation triggered by diabetes, in men, but not in postmenopausal women.