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A number of studies on visceral leishmaniasis VL vector control have been conducted during the past decade, sometimes came to very different conclusion. The present study on a large sample investigated different options which are partially unexplored including: 1 indoor residual spraying IRS with alpha cypermethrin 5WP; 2 long lasting insecticide impregnated bed-net LLIN ; 3 impregnation of local bed-nets with slow release insecticide K-O TAB KOTAB ; 4 insecticide spraying in potential breeding sites outside of house using chlorpyrifos 20EC OUT and different combinations of the above.
The study was a cluster randomized controlled trial where houses from 11 villages were divided into 10 sections, each section with 6 clusters and each cluster having approximately 50 houses. Based on vector density males plus females during baseline survey, the 60 clusters were categorized into 3 groups: 1 high, 2 medium and 3 low.
Each group had 20 clusters. From these three groups, 6 clusters about households were randomly selected for each type of intervention and control arms. Vector density was measured before and 2, 4, 5, 7, 11, 14, 15, 18 and 22 months after intervention using CDC light traps.
The impact of interventions was measured by using the difference-in-differences regression model. A total of 17, sand flies were collected at baseline and during the surveys conducted over 9 months following the baseline measurements. At baseline, the average P. The intervention results presented as the range of percent reductions of sand flies males plus females and rate ratios in 9 measurements over 22 months. Operationally, this is much easier to apply than IRS. A cost analysis of the preferred tools will follow.
