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Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. Sophias Ave. The data presented in this study are available upon reasonable request from the corresponding author. The data are not publicly available due to privacy restrictions. The relative frequencies of typical and atypical or mixed presentations within the entire spectrum of AD remain unclear, while some mixed or atypical presentations may have not received adequate attention for them to be included in diagnostic criteria.

Additionally, The remaining Despite selection bias academic center , atypical clinical presentations of AD may be more common than previously thought. CSF biomarkers seem to be a useful tool for antemortem identification of such patients, which is likely to affect therapeutic decisions.

Some of the unusual presentations described above should be incorporated in diagnostic criteria. With time, due to the results of pathological studies, it became evident that AD patients may present at pre-dementia stages [ 2 ] or with atypical pictures in the form of various syndromes, including primary progressive aphasia PPA [ 3 ], corticobasal syndrome CBS [ 4 ], posterior cortical atrophy PCA [ 5 ], and frontotemporal dementia FTD -like syndrome [ 6 ], or a mixture of other conditions, including cerebrovascular [ 7 ] and Lewy body pathology [ 8 ].

This expanded concept of AD [ 12 ] has been at least partly incorporated in recent diagnostic criteria [ 13 , 14 , 15 ]. Early and accurate diagnosis of unusual clinical presentations of AD, as well as exclusion of other primary [ 16 ] or secondary [ 17 , 18 ] causes of dementia, reduces uncertainty and may have significant implications in therapeutic decisions and predictions of prognosis.