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Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. The raw data supporting the conclusions of this article will be made available by the authors, without undue reservation. Chronic Chagas cardiomyopathy CCC is the most frequent and severe form of Chagas disease, a neglected tropical illness caused by the protozoan Trypanosoma cruzi , and the main cause of morbimortality from cardiovascular problems in endemic areas.
Although efforts have been made to understand the signaling pathways and molecular mechanisms underlying CCC, the immunological signaling pathways regulated by the etiological treatment with benznidazole Bz has not been reported. In comparison with non-infected mice, 30 genes were upregulated, and 31 were downregulated in infected mice. Bz therapy restored the expression of genes related to inflammatory response, cellular development, growth, and proliferation, and tissue development pathways, most probably linked to the cardiac remodeling processes inherent to CCC, thus mitigating the Th1-driven response found in vehicle-treated infected mice.
Altogether, our results contribute to the better understanding of the molecular mechanisms of the immune response in the heart tissue in chronic Chagas disease and reinforce that parasite persistence and dysregulated immune response underpin CCC severity.
Chagas disease CD or American trypanosomiasis is an infectious disease caused by the protozoan parasite Trypanosoma cruzi , responsible for an estimated 6 to 7 million people infected and approximately 75 million at risk of infection World Health Organization, However, as globalization and migration mobility accelerated over the years, CD has disseminated to countries not originally endemic, such as United States, Spain, Japan, and Australia Rassi et al.
