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Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. In most developed countries, incidence of cervical cancer declined likely due to well-established cervical cancer screening programs. However, such decline has not been identified in Eastern Europe, where such programs are not well established.

This study utilized data of the Bulgarian Cancer Registry for the period — Age-standardized incidence and mortality trends were analyzed using Joinpoint regression. Maps were created to illustrate spatial distributions of rates. The distribution of disease stages changed over the 21 years, with most common stages of diagnosis being stage II in While age-standardized mortality slightly increased over the 21 years from 4.

The lack of a similar plateau in mortality may be because the second most prevalent stage of diagnosis in recent years was stage III, indicating diagnosis at advanced symptomatic stages. Cervical cancer incidence is expected to continue to decrease if screening programs are strengthened and human papillomavirus vaccines are widely utilized. As Bulgaria has shared cervical cancer trends with other Eastern European countries in the past, it may be beneficial to develop future prevention interventions based on a regional, rather than a country-specific level.

In , cervical cancer had the third highest age-standardized incidence rate for cancers affecting women worldwide, and ranked within the top five cancers affecting women for mortality [ 1 ]. Cervical cancer is unique in that its risk factors are well established and it is considered highly preventable through vaccination and early detection by screening.