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Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. Advanced or recurrent endometrial cancer EC no longer amenable to surgery or radiotherapy is a life-threatening disease with limited therapeutic options left.

This phase 2 trial was performed to assess the efficacy and safety of AEZS in this group of patients. Prior anthracycline therapy was not allowed. Patients received AEZS as a 2-hour infusion on day 1 of a day cycle. The treatment was continued for a maximum of 6 to 8 cycles. The primary end point was the response rate determined by the Response Evaluation Criteria in Solid Tumors.

Forty-three of these patients were eligible. The median time to progression was 7 months, and the median overall survival was 15 months. Endometrial cancer EC is the most common malignancy of the genital tract of women living in industrialized countries. In the European Union, nearly 64, women are estimated to be diagnosed with EC, and 14, are estimated to die of this disease in Prognosis is poor for these women with a median overall survival OS of only approximately 12 months for patients enrolled in clinical trials.

AEZS was shown to bind with high-affinity to LHRH-specific receptors on human breast, endometrial and ovarian cancer cells, and on biopsy specimens. Previous endocrine or non—anthracycline-based chemotherapies adjuvant or first-line palliative therapies were allowed.