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Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. A year-old Japanese man presented to our hospital complaining of left chest pain and rash on the hands and feet. Plain thoracic computed tomography CT revealed multiple nodular shadows in the left lower lobe of the lung.

A diagnosis of secondary syphilis was made based on the appearance of the rash and positive serologic tests for syphilis.

The patient was started on amoxicillin but was switched to minocycline due to amoxicillin-induced rash on both forearms. Thoracic CT after five months of treatment revealed that the multiple lung nodular shadows had contracted, and secondary syphilis with pulmonary involvement was diagnosed. The global incidence of syphilis was Although the incidence is decreasing year by year in Africa, where the disease is most prevalent 3 , the yearly incidence in Japan has been rising since ; the 4, cases reported in represented a 7.

In Japan, the incidence of syphilis among women as well as among men who have sex with men MSM is rising at a rate similar to that of the United States 4 , 5. Left untreated, syphilis gradually progresses through several stages, including a period of latency: primary, secondary, early latent, late latent, and tertiary. In primary syphilis, Treponema pallidum subsp.

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