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Androgens are considered to have immunomodulatory effects but their cellular mechanisms of action remain largely unknown. Analyses were performed before therapy and at 1, 3, 6 and 12 months after treatment with mg testosterone enanthate every 2 weeks in a group of 13 type-2 diabetic men. These results confirm and extend previous observations about the anti-inflammatory effects of androgen therapy on APCs in a new, previously unexplored model of androgen deficiency; namely, aging type-2 diabetic men.

A decreased production of inflammatory cytokines by APCs might have important consequences for sex differences in susceptibility to autoimmune diseases, inflammatory response to injury and atheromatosis. Aging in men is associated with a progressive decrease in serum testosterone levels and an increase in the prevalence of hypogonadism Harman et al.

Although the age-related decrease in testosterone levels is independent of health status Harman et al. The partial androgen deficiency detected in aging men has been related to the development of multiple symptoms and signs, and it has been shown that androgen-replacement therapy may induce improvements of lean body mass Tenover , Snyder et al.

Nevertheless, present information about the benefits and risks of testosterone replacement is limited and there is consensus about the need for further studies in which the effects of androgen replacement in aging males can be evaluated American Society for Reproductive Medicine , Snyder Further insight into this field may contribute to the understanding of the mechanisms involved in the beneficial effects of androgens on the immune system Malkin et al.