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Obesity alters adipose tissue metabolic and endocrine function and leads to an increased release of fatty acids, hormones, and proinflammatory molecules that contribute to obesity associated complications.

To further characterize the changes that occur in adipose tissue with increasing adiposity, we profiled transcript expression in perigonadal adipose tissue from groups of mice in which adiposity varied due to sex, diet, and the obesity-related mutations agouti Ay and obese Lepob.

We found that the expression of 1, transcripts correlated significantly with body mass. Similar relationships were found in human subcutaneous adipose tissue stained for the macrophage antigen CD Adipose tissue macrophage numbers increase in obesity and participate in inflammatory pathways that are activated in adipose tissues of obese individuals.

Stuart P. Leibel, Anthony W. Ferrante Jr. Go to JCI Insight. Citations to this article. Obesity is associated with macrophage accumulation in adipose tissue.