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It has a high mortality rate and is the third most common invasive fungal infection. Culture and biopsy of the affected areas were performed, confirming by histopathology and isolation a rhino-orbito-cerebral mucormycosis due to Actinomucor elegans. The patient was treated with specific antifungal therapy as an inpatient and left the service after obtaining negative cultures, continuing with outpatient antifungal treatment.

Mucormycosis is an acute or subacute, rapidly progressive and highly fatal opportunistic infection, caused by fungi of the order Mucorales, being Rhizopus spp. Mucormycosis has acquired more importance during the COVID pandemic and it has been reported a significant increase in the number of mucormycosis cases around the world associated with COVID, particularly in India [ 4 ]. Mucormycosis mainly affects immunosuppressed patients, patients with hematological malignancies, transplant recipients, uncontrolled diabetic patients, among others [ 5 ].

It is classified into six clinical forms: rhino-orbito-cerebral, pulmonary, cutaneous, gastrointestinal, disseminated and infrequent rare forms e. Rhino-orbito-cerebral mucormycosis is the most common form in diabetic patients and the second most common form in oncologic and transplant patients.