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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Immunosensors are used to detect the presence of certain bio-reagents mostly targeted at the diagnosis of a condition or a disease.
Here, a general purpose electrical immunosensor has been fabricated for the quantitative detection of multiple bio-reagents through the formation of an antibody-antigen pair. The sensors were fabricated using all printing approaches. The sensors were then treated with three different types of antibodies that were immobilized by physisorption into the highly porous multi-layered structure of MoS 2 active layer.
IgG was then selected to test the sensors for point of care POC diagnosis through a specially designed electronic readout system for sensors and interfacing it with a smartphone using Bluetooth connection. The sensors showed promising performance in terms of stability, specificity, repeatability, sensitivity, limit of detection LoD , and range of detection RoD. Immunosensors are compact analytical devices that are used to detect the formation of a complex resulting from an antigen-antibody interaction using transduction techniques to generate an interpretable and process able output signal.
The different types of transducing mechanisms are based on difference in generated signals or changes in properties when a complex is formed 1. Immunosensors are well recognized standard bio detection devices employed in laboratories for disease diagnosis, food industry for safety testing, and for general environmental contamination monitoring.