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Rootline Navigation Eawag - das Wasserforschungsinstitut des ETH-Bereichs Umweltmikrobiologie Publikationen Abteilung Umweltmikrobiologie. Bagutti, C. Association between the number of symptomatic mpox cases and the detection of mpox virus DNA in wastewater in Switzerland: an observational surveillance study.

Swiss Medical Weekly , , Aim of the study: The COVID pandemic has drawn attention to the benefit of wastewater-based epidemiology, particularly when case numbers are underreported. Underreporting may be an issue with mpox, where biological reasons and stigma may prevent patients from getting tested.

Therefore, we aimed to assess the validity of wastewater surveillance for monitoring mpox virus DNA in wastewater of a Central European city and its association with official case numbers. Methods : Wastewater samples were collected between 1 July and 28 August in the catchment area of Basel, Switzerland, and the number of mpox virus genome copies they contained was determined by real-time quantitative PCR. Logistic regression analyses were used to determine the odds of detectability of mpox virus DNA in wastewater, categorised as detectable or undetectable.