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The effort to develop vaccines based on economically accessible technological platforms available by developing countries vaccine manufacturers is essential to extend the immunization to the whole world population and to achieve the desired herd immunity, necessary to end the COVID pandemic.
After purification by immobilized metal ion affinity chromatography and hydrophobic interaction chromatography, the RBD protein was characterized by mass-spectrometry, circular dichroism, and binding affinity to angiotensin-converting enzyme 2 ACE2 receptor. The recombinant protein shows high antigenicity with convalescent human sera and also with sera from individuals vaccinated with the Pfizer-BioNTech mRNA or Sputnik V adenoviral-based vaccines.
These data suggest that the RBD recombinant protein expressed in yeast P. The pandemic caused by SARS-CoV-2 has demonstrated the need to modify the way that public health, the governmental role, and international cooperation in science and health have been functioning up to now. Cuba is an example of a global vision of public health and stands out for the strength of its biotechnology industry where one of the main achievements is the production of the Hepatitis B recombinant vaccine in yeast P.
As a result, the incidence of acute hepatitis B in the country has decreased down to less than 50 cases and acute hepatitis B in children under 5 years old has not been reported since the year [ 4 ].