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Many millions of people use various of nonsteriodal anti-inflammatory drugs NSAIDs on daily basis, thus range this group of drugs among one of the most prescribed ones in the world. Center for Disease Control in Atlanta, U. Celecoxib is used to diminish signs and symptoms of osteoarthritis OA and rheumatoid arthritis RA of adults and in treatment of familial adenomatous polyposis FAP. Rofecoxib is used to diminish signs and symptoms of OA, in treatment of acute pain in adults and in primary dysmenorrhea.
Data suggest that COX-2 specific inhibitors could be efficient in colon cancer prevention. Celecoxib and rofecoxib have been registered in in Czech republic, celecoxib for treatment of osteoarthritis and rheumatoid arthritis, rofecoxib for treatment of osteoarthritis. D 2 , MUDr. Abramson S. Arthritis Rheum ; 1. N Engl J Med ; Bjarnason I. Gastroenterology ; Bjarnason I: The effects of nonsteroidal anti-inflammatory drugs on the small and large intestine s.
Skokie: AM Medica Commun, Brooks P. Novinky z gastroenterologie ; 4 2 : Praha: Grada Publishing, v tisku. Cannon G. Arthritis Rheum ; S DeWitt D. Am J Med ; 40S. Arthristis Rheum ; 44, Dubois R. Dunn M. Am J Kidney Dis ; Eberhart C. Emery P. Lancet ; Ferguson S. J Am Soc Nephrol ; Epidemiology and risk appraisal. J Rheumatol ; 28, Suppl: Arthritis Rheum ; 43 Suppl 9.
Giovannucci E. Hawkey CJ: Risk of ulcer bleeding in patients infected with Helicobacter pylori taking non-steroidal antiinflammatory drugs. Gut ; Komhoff M. Kidney Int ; Remedia ; Langman M. JAMA ; Lanza F. Am J Gastroenterol ; Lipsky P.