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Performance of Panel-Estimated GFR Among Hospitalized Older Adults

However, few studies in this population have evaluated the performance of equations for estimating the glomerular filtration rate GFR -particularly those that incorporate multiple filtration markers. Study design: Cross-sectional diagnostic test substudy of a randomized clinical trial. Limitations: Only White patients were included; only a subset of patients from the original clinical trial underwent GFR measurement; and filtration marker concentration can be affected by subclinical changes in volume status.

Trial registration: Registered at ClinicalTrials. Plain-language summary: Inaccurate kidney function assessment can lead to medication errors, a common cause of hospitalization and early readmission among older adults. Several novel methods have been developed to estimate kidney function based on a panel of kidney function markers that can be measured from a single blood sample. We evaluated the accuracy of these new methods relative to a gold standard method among hospitalized older adults.

We found that kidney function estimates combining 2 markers creatinine and cystatin C were highly accurate and noticeably more accurate than estimates based on creatinine alone. Published by Elsevier Inc. All rights reserved. Publication types Randomized Controlled Trial. Substances Cystatin C Creatinine Biomarkers. Associated data ClinicalTrials.

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