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Metrics details. The MRI findings and thresholds used to define disc degeneration vary in the literature, and their associations with low back pain LBP remain uncertain. To explore how various thresholds of lumbar disc degeneration alter the association between disc degeneration and self-reported LBP. An exploratory, cross-sectional cohort study of a general population. The MRI variables, signal intensity Grades 0—3 and disc height Grades 0—3 , were dichotomised at different thresholds.
Logistic regression analyses were used to determine associations. Receiver Operating Characteristic curves were used to investigate differences between diagnostic values at each threshold. At ages 45 and 49, the difference in ORs exceeded 0. At age 49, differences in ORs exceeded 0. Differences between AUC were not statistically significant. The results suggest that the thresholds used to define the presence of lumbar disc degeneration influence how strongly it is associated with LBP.
Thresholds at more severe grades of disc signal and disc height loss were more strongly associated with LBP at age 41, but thresholds at moderate grades of disc degeneration were most strongly associated with LBP at ages 45 and Peer Review reports.
Low back pain LBP is a common health problem that results in a large global burden both personally and financially [ 1 ]. Understanding of the causes of LBP remains limited. In a meta-analysis by Brinjikji et al. An overall odds ratio OR of 2.
