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Environmental Health volume 22 , Article number: 46 Cite this article. Metrics details. Perfluoroalkyl substances PFAS are persistent chemicals used in everyday consumer products leading to ubiquitous human exposure. Findings of impaired neurodevelopment after prenatal exposure to PFAS are contradictory and few studies have assessed the impact of postnatal PFAS exposure.
Language development is a good early marker of neurodevelopment but only few studies have investigated this outcome separately. We therefore investigated the association between prenatal and early postnatal PFAS exposure and delayed language development in 18 to month-old Danish children. The Odense Child Cohort is a large prospective cohort. From to all newly pregnant women residing in the Municipality of Odense, Denmark was invited to participate. Language scores were converted into sex and age specific percentile scores and dichotomized to represent language scores above or below the 15th percentile.
We applied Multiple Imputation by Chained Equation and conducted logistic regressions investigating the association between prenatal and early postnatal PFAS exposure and language development adjusting for maternal age, pre-pregnancy BMI, education and respectively fish intake in pregnancy or childhood and duration of breastfeeding in early postnatal PFAS exposure models.
We found no significant associations between neither prenatal nor early postnatal PFAS exposure and language development among mother-child pairs. In this low-exposed cohort the finding of no association between early postnatal PFAS exposure and language development should be interpreted with caution as we were unable to separate the potential adverse effect of PFAS exposure from the well documented positive effect of breastfeeding on neurodevelopment.