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Longitudinally, we investigated the associations between these liver enzymes and changes in cognitive performance over the course of a year. Logistic and linear regression models were used to analyze these associations and mediation analyses were conducted to assess whether age and amyloid PET burden mediated these associations. Further research is required to elucidate the underlying mechanisms and potential therapeutic implications of these findings.

AD is a complex neurodegenerative disorder due to its multifactorial etiology, involving a combination of genetic susceptibilities and environmental factors Hampel et al. Despite advances in understanding the molecular pathogenesis of AD, current diagnostic approaches and therapeutic interventions remain inadequate.

This attention to peripheral organ involvement unveils novel avenues for understanding pathophysiology of AD and identifying accessible biomarkers. However, conflicting findings from other studies have challenged this association Kamada et al.

These inconsistencies could be attributed to differences in the study designs, sample sizes, population demographics, methodologies, the specific liver function markers assessed, and the statistical approaches employed.