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Objective Infections are a common complication of SLE. Our objective was to evaluate their causes and impact on the survival of patients with SLE. Methods Analysis of the admissions and death causes in patients diagnosed with SLE from the Spanish Hospital Discharge Database and the infection-related deaths of the Spanish population from the National Statistical Institute, between and Only infections recorded as the main diagnosis were analysed severe or clinically relevant infection.
Conclusion Our nationwide study confirms that infections are the leading cause of death in SLE in Spain, with the highest proportion occurring in young patients with lupus compared with the general population of the same age range. You will be able to get a quick price and instant permission to reuse the content in many different ways.
Infections are one of the key determinants of early morbidity and mortality of patients with SLE, strongly linked to disease activity and immunosuppression. Since infection is the main factor accounting for the high age-standardised mortality rate identified in patients with lupus, measures mitigating its impact on this population should be reinforced, such as a rational use of immunosuppression and glucocorticoids, vaccination and prompt identification and treatment of infection.
SLE is a complex and heterogenic autoimmune disease that mainly affects women at a young age. The SNHDD includes demographic and epidemiological data and up to 20 diagnoses carried out during admissions. These diagnoses were retrieved according to the discharge reports, and in case of decease, also according to the death certificate.