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Background and Objectives: The influence of age at diagnosis of breast cancer upon the prognosis of patients with different immunohistochemical IHC -defined subtypes is still incompletely defined.

Our study aimed at examining the association of age at diagnosis and risk of breast cancer-specific mortality BCSM. Methods: , eligible breast cancer patients were obtained for our study cohort using the Surveillance, Epidemiology, and End Results database from to A Cox proportional hazards model was used for multivariate analysis.

A multivariable fractional polynomial model within the Cox proportional hazards model was used to evaluate the relationship between age at diagnosis and the risk of BCSM.

Results: For the whole cohort, the median follow-up time was 43 months. Breast cancer is the most common cancer in females. In , it is estimated that , new breast cancer cases and 42, breast cancer deaths will occur in the United States alone 1. Breast cancer is a heterogeneous disease, which the St. Gallen Consensus classified into four main molecular subtypes: luminal A, luminal B, HER2-enriched, and basal-like breast cancer 2 — 4.