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Although significant therapeutic benefits have been observed, life-threatening adverse pulmonary events have been reported. Methods: Using SAS 9. Among these CAR-T cell-related AEs, hypoxia was the most frequently reported cases , followed by respiratory failure cases.
Specifically, Tisa-cel was associated with severe events including respiratory failure and hypoxia, whereas Axi-cel was strongly correlated with both hypoxia and tachypnea. Notably, the majority of these PAEs occurred within the first 30 days post-treatment. The fatality rates varied among the different CAR-T therapies, with Tisa-cel exhibiting the highest fatality rate These CAR-T cell therapy-associated events are clinically significant and merit the attention of clinicians and researchers.
Since the approval of the first chimeric antigen receptor T-cell CAR-T therapy, Tisagenlecleucel tisa-cel , on 30 August , the landscape of chimeric antigen receptor T-cell CAR-T products has evolved significantly. As of September , the U.
These products and their indications are listed in Table 1 Munshi et al. Compared with traditional drugs, CAR-T therapy has shown remarkable efficacy in multiple clinical trials for the treatment of hematological malignancies Maude et al. Multiple drug regulatory agencies, including the FDA, have approved over clinical trials of CAR-T cell therapy for both hematological and solid tumors. The use of CAR-T cells is expected to increase rapidly in the coming years, thereby benefiting more patients.
