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Effective date : Year of fee payment : 4. Disclosed is use of alphavirus in preparation of antitumor drugs. The alphavirus is M1 virus or Getah virus. In addition, the specific tumor types sensitive to abovementioned alphavirus treatment are further determined, so as to provide a safe and effective solution for antitumor drug administering schemes.

The present disclosure belongs to the technical field of biomedicine, and it relates to use of alphavirus in preparation of antitumor drugs. Tumors derive from accumulative change of genes and epigenetics in normal cells, such change promotes conversion of normal cells into malignant tumors. This complex pathological change process determines diversity of mechanisms of genesis, maintenance and metastasis in different tumors.

At present, surgical excision, chemotherapy and radiotherapy are common methods for clinical therapy of tumors, however surgical excision of tumors is prone to recur, and toxic and side effects of the radiotherapy and the chemotherapy are obvious. Alphavirus belongs to Togaviridae, and it is a type of single stranded RNA virus with an envelope structure, transmitted mainly by a transmission media of arthropod.

Knipe, Peter M. Howley, Chapter 23, Alphaviruses, Fields Virology 6 th edition: , Venezuelan equine encephalitis virus of alphaviruses can act as a vector to transduce dendritic cells so as to treat tumors Moran T P, Burgents J E, Long B, et al: Alphaviral vector-transduced dendritic cells are successful therapeutic vaccines against neu-overexpressing tumors in wild-type mice.