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A ground-breaking study, published in Nature Human Behaviour , reveals a significant association between 74 early-life diseases and the likelihood of remaining childless throughout one's life, with 33 of these diseases prevalent in both women and men.

Led by Aoxing Liu and senior authors Melinda Mills , Andrea Ganna and an international team, the study examined the link between early-life diseases and lifetime childlessness in over 2. Although multiple social, economic and individual preferences have been studied, there has been limited research examining the contribution of different diseases to being childless over a lifetime, particularly those diseases with onset prior to the peak reproductive age. Our study is the first to systematically explore how multiple early-life diseases relate to lifetime childlessness and low parity in both men and women.

Schematic overview of the study. Using nationwide registers, the researchers analysed information on early-life disease diagnoses for 1. All were alive at the age of 16, did not emigrate, and had mostly finished their reproductive years by the end of defined as age 45 for women, and age 50 for men. Interestingly, the association between disease and childlessness was more alike between childless individuals and their siblings who had only one child, in comparison to those with more children.

Out of the 74 diseases significantly associated with childlessness in at least one sex, including the 33 shared among women and men, more than half of these were mental-behavioural disorders.