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Importance: Previous studies evaluating the association of patient sex with clinical outcomes using conventional thermal ablative modalities for atrial fibrillation AF such as radiofrequency or cryoablation are controversial due to mixed results.

Pulsed field ablation PFA is a novel AF ablation energy modality that has demonstrated preferential myocardial tissue ablation with a unique safety profile. All patients underwent pulmonary vein isolation and additional ablation, which was performed at the discretion of the operator.

Main outcomes and measures: The primary effectiveness outcome was freedom from clinically documented atrial arrhythmia for 30 seconds or longer after a 3-month blanking period. Results: Of patients mean [SD] age, Pulmonary vein isolation was performed in Additional ablation was performed in The 1-year Kaplan-Meier estimate for freedom from atrial arrhythmia was similar in male and female patients There was also no significant difference in acute major AEs between groups male, 1.

Conclusion and relevance: Results of this cohort study suggest that after PFA for AF, there were no significant sex differences in clinical effectiveness or safety events. Abstract Importance: Previous studies evaluating the association of patient sex with clinical outcomes using conventional thermal ablative modalities for atrial fibrillation AF such as radiofrequency or cryoablation are controversial due to mixed results. Publication types Research Support, Non-U.