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Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. Restless legs syndrome RLS is etiologically divided into primary and secondary syndromes. However, a comparative description of both types is lacking in the literature. We compared primary and secondary RLS with respect to demographic determinants, associated risk factors, and comorbidities. Cases were assessed with an interview-based questionnaire regarding baseline characteristics, risk factors, and comorbidities and with lower limb examinations and laboratory measurements.
In total, 78 patients with RLS, including 50 Male gender and ethnicity play significant roles in primary RLS, whereas female gender and iron deficiency may be the main risk factors associated with secondary RLS. In , Sir Thomas Willis described a medical condition that caused restlessness and unpleasant sensations in the limbs, mostly during rest periods or before sleep.
Ekbom provided a detailed description of the disease currently known as restless legs syndrome RLS or Willis—Ekbom disease. RLS is a chronic sensorimotor neurological disorder affecting mostly the limbs, causing an unpleasant sensation that triggers an irresistible urge to move the affected limb, which provides temporary relief.
RLS mostly occurs during rest and at sleep time and can severely affect quality of life by causing chronic insomnia, sleep deprivation, anxiety, depression,[ 4 ] decreased cognition,[ 5 ] and even cardiovascular disorders.