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Federal government websites often end in. The site is secure. Preview improvements coming to the PMC website in October Learn More or Try it out now. The skin is important for the perception of health and beauty. Knowledge of the physiological, chemical, and biophysical differences between the skin of male and female patients helps dermatologists develop a proper approach not only for the management of skin diseases but also to properly take care of cosmetic issues.

The influence of genetic and environmental factors on skin characteristics is also critical to consider. A literature search of PubMed and Google was conducted to compare the biophysical and biomechanical properties of the skin of male and female patients using the keywords "skin", "hydration", "water loss", "sebum", "circulation", "color", "thickness", "elasticity", "pH", "friction", "wrinkle", "sex", "male", and "female". A total of titles were found. After removing duplications and non-English papers, the number was reduced to Of the titles, 57 were deemed suitable for inclusion in this review.

The studies show that the skin parameters of hydration, transepidermal water loss, sebum, microcirculation, pigmentation, and thickness are generally higher in men but skin pH is higher in women. These parameters can be considered as age markers in some cases and are susceptible to change according to environment and life style. Biometrological studies of the skin provide useful information in the selection of active principles and other ingredients of formulations to develop a specific approach for cosmetic treatments.

The skin is the largest multifunctional organ in the body. It functions as a protective physical barrier by absorbing ultraviolet radiation and preventing microorganism invasion and chemical penetration. The skin also controls the passage of water and electrolytes and has a major role in the thermoregulation of the body, in addition to its immunological, sensory, and autonomic function. Understanding the physiological, chemical, and biophysical characteristics of the skin helps us develop a proper approach for the management of skin diseases.

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