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In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Inter-organ communication is a major hallmark of health and is often orchestrated by hormones released by the anterior pituitary gland. Pituitary gonadotropes secrete follicle-stimulating hormone FSH and luteinizing hormone LH to regulate gonadal function and control fertility. Here, we find that gonadotrope depletion in adult female mice triggers profound hypogonadism, obesity, glucose intolerance, fatty liver, and bone loss.

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