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Between 23 and 26 May , the international scientific conference on angioedemas—conditions belonging to the group of orphan diseases and resulting in a life-threatening condition—will be held on the eleventh occasion in Budapest This designation better reflects the agenda of the 4-day long conference, because it has become a forum for discussing topics also on other bradykinin-mediated hereditary and acquired angioedemas, in addition to C1-inhibitor deficiency.

Based on the 82 submitted abstracts, the programme includes 36 oral and 46 poster presentations. These will be supplemented by the lectures delivered by P atricia P ozo -R osich Barcelona, Spain on the relationship between migraine and angioedema, as well as by M ichael K irschfink Heidelberg, Germany on the standardization of the laboratory methods applied for complement testing.

Furthermore, A vner R eshef Ashkelon, Israel will summarize the prodromal symptoms of angioedema. By tradition, the agenda of the conference comprises consensus meetings and roundtable discussions intended to facilitate the adoption of international guidelines. This year, A nastasios E. The geographical distribution and professional background of the participants are variegated. This educational activity is supported by an independent medical educational grant from Shire Takeda.

Finally, A llen K aplan will summarize for the audience all the topics and findings discussed at this Workshop. Pathophysiologically, migraine is a genetically-driven, cycling functional disorder affecting several areas of the brain, ultimately leading to an excessive activation of trigeminovascular afferents in the meninges. Through multiple pathways local release of inflammatory peptides as calcitonin gene-related peptide CGRP , substance P, VIP and bradykinin are presumable.