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Research Interests Epigenetics in reproduction, spermatogonial stem cell self-renewal, silencing of transposable elements, piRNA biogenesis, m6A RNA modification, regulation of meiosis, DNA recombination, chromosome segregation, DNA double-strand break repair, chromosome synapsis, male infertility in humans.
Meiosis, a cell division unique to germ cells, allows the reciprocal exchange of genetic material between paternal and maternal genomes.
Meiosis generates the genetic diversity necessary for evolution of species. Abnormality in meiosis is a leading cause of birth defects and infertility.
Spermatogonial stem cells are the adult male germline stem cells and responsible for life-long production of sperm. Our research interests include molecular genetics of chromosomal synapsis, DNA double-strand break repair, homologous recombination, self-renewal of spermatogonial stem cells, genetic causes of male infertility in humans, and piRNA biogenesis.