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Despite the critical role of mitochondria in maintaining cellular function, including energy production, the associations between muscle mitochondrial energetics and frailty have not been widely explored in a large, well-phenotyped, older population. We estimated the proportional odds ratio POR for greater frailty, adjusted for multiple potential confounders. Muscle energetics was most strongly associated with slowness and low physical activity components.

On the other hand, we did observe differential relationships between measures of muscle mitochondrial energetics and the individual components of frailty. Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you. Skip to main content. Email Facebook. Lower muscle mitochondrial energetics is associated with greater phenotypic frailty in older women and men: the Study of Muscle, Mobility and Aging.

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