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In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Recent genome-wide association studies of colorectal cancer CRC have identified common single-nucleotide polymorphisms SNPs mapping to 10 independent loci that confer modest increased risk. These studies have been conducted in European populations and it is unclear whether these observations generalise to populations with different ethnicities and rates of CRC.

Twelve of the SNPs showed evidence of an association. The strongest associations were provided by rs on 10p14, rs on 15q14 and rs on 18q Possible reasons for failure of replication for some loci include inadequate study power, differences in allele frequency, linkage disequilibrium structure or effect size between populations.

Our results suggest that many associations for CRC are likely to generalise across populations. It is currently the third commonest malignancy and the fourth commonest cause of cancer-related mortality in the world Stewart et al, The overall burden of the disease is set to increase further from the increasing incidence rates in Asian and African populations associated with the adoption of western diets Tenesa and Dunlop, These GWAS have been performed almost exclusively in populations of European ancestry, and the effects of these risk alleles in other populations are as yet unknown.