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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Aldehyde dehydrogenase 2 ALDH2 is a mitochondrial enzyme that metabolizes ethanol and toxic aldehydes such as 4-hydroxynonenal 4-HNE.

The role of 4-HNE in stroke in humans was also suggested by persistent elevation of its plasma levels for at least 6 months after stroke. Lastly, we observed that 21 of 1 subjects followed for 8 years who developed stroke had higher initial plasma 4-HNE levels than those who did not develop stroke. These findings suggest that activation of the ALDH2 pathway may serve as a useful index in the identification of stroke-prone subjects, and the ALDH2 pathway may be a potential target of therapeutic intervention in stroke.

Stroke is an age-related disease and the second most common cause of death 1 , 2. The incidence of stroke could be reduced by control of risk factors, such as high blood pressure, elevated blood cholesterol, cigarette smoking, carotid stenosis, diabetes mellitus and heart failure state. The unidentified risk factors for stroke, combined with unsatisfactory control of known risk factors e.

Identification of new risk factors may result in the development of new strategies for prevention and treatment of stroke. Oxidative stress is one of the most important factors that contribute to ischemic injury. Reactive aldehydes generated from oxidized lipids, such as malondialdehyde MDA and 4-hydroxy-transnonenal 4-HNE , have been detected in almost all tissues that are subjected to ischemia.

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