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Metrics details. Zinc and copper are essential trace elements and play a crucial role in the homeostasis of connective tissues. In this study, we aimed to define zinc and copper levels in the vaginal tissue and establish whether a correlation exists between the zinc and copper levels either or both in whole blood or vaginal tissue samples and whether the finding correlates with the age of the patient or at least with her menopausal status.

We collected whole blood and vaginal tissue samples from 32 women and measured their zinc and copper levels by inductively coupled plasma optical emission spectrometry.

Zinc and copper levels in the vaginal tissue decline with age. Peer Review reports. Zinc Zn is an essential trace-metal of the human body, where 2—4 g [ 1 ] of it is distributed in the brain, muscle, bones, kidney, and liver, with the highest concentrations in the prostate and the eye [ 2 ].

The total amount of copper Cu in the human body is 75— mg, making it the third most common trace metal after iron and zinc [ 3 ]. Copper is needed for the iron metabolism and many other biological processes, like the neuropeptide synthesis and immune functions [ 4 , 5 ], and vital for both antioxidant and pro-oxidant biochemical processes [ 6 , 7 ].