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In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Late-life depression LLD is associated with an increased risk of developing dementia; however, it is not known whether individuals with a history of LLD exhibit a more rapid rate of cognitive decline. We aimed to determine whether those with LLD experienced faster cognitive decline compared with never-depressed control NDC participants from the community and whether stratification of LLD into early-onset depression EOD and late-onset depression LOD subtypes revealed differing rates and domain-specific expression of cognitive decline.

We conducted a prospective, longitudinal study where participants with LLD remitted and NDC were followed for 5 years on average. Every year, participants underwent comprehensive neuropsychological assessment. Composite scores for each cognitive domain were calculated through averaging standardized scores across tests.

Our findings suggest that baseline impairment may lower the threshold for those with LLD to develop dementia. EOD and LOD may represent distinct phenotypes of cognitive impairment with differing neural substrates. LOD may represent a distinct phenotype with a more rapid decline in verbal skills and delayed memory. Late-life depression LLD is a leading contributor to psychiatric and medical morbidity and mortality in older adults 1.