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Background: 2, 4-dichlorophenoxyacetic acid 2,4-D is one of the most frequently used herbicides in the world, and it has been linked with low testosterone; however, studies regarding its effect on erectile function are limited. ED was assessed by a single, validated survey question. Multivariable logistic regression analysis utilizing sampling weights was performed to determine the relationship between 2,4-D exposure and ED.
Results: Multivariable logistic regression models demonstrated no statistically significant association between 2,4-D exposure and ED after full adjustment [odds ratio OR 1. Furthermore, the association between urinary 2,4-D level and ED was not significant in the subgroup analysis stratified by age, BMI, cardiovascular disease, hypertension, diabetes, and high cholesterol.
Conclusion: We demonstrated that there was no association between 2,4-D exposure and ED. Further studies are warranted to corroborate our results.
Erectile dysfunction ED , defined as the persistent inability to achieve or maintain a penile erection sufficient for successful vaginal intercourse, is the most common disorder affecting middle-aged and older men 1. Furthermore, it is estimated that more than million men globally experience ED by 3. The trends pose a great challenge for public health systems to develop policies to prevent or alleviate ED. Herbicides are a large class of synthetic compounds that have been widely utilized to control broadleaf weeds.
