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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer.
In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Background: The use of opioid-based therapies in patients with chronic pain is a challenge in the medical practice because of drug abuse liability. This problem is magnified in the case of patients with a previous history of opioid abuse leading to reduced treatment of pain conditions in this population. Surprisingly, few studies have investigated how chronic pain could alter opioid intake patterns and none of them have focused in an opioid dependent population.
In addition, although it is known that opioid reinforcement is mediated through the activation of the mesolimbic dopamine DA neurons projecting from the ventral tegmental area VTA to the nucleus accumbens NAc , there is uncertainty about the effects of pain on DA transmission within these brain areas and whether pain-induced effects on DA transmission within the VTA-NAc pathway may impact the reinforcing properties of opioids.
Methods: In the present study, we investigated the effects of chronic inflammatory pain on i. We selected the complete Freund's adjuvant CFA rat model of inflammation to assess the effect of chronic inflammatory pain on opioid abuse. In addition, we investigated the neurochemical changes induced by chronic inflammatory pain on DA transmission within the mesolimbic pathway by conducting in vivo microdialysis studies.