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Football Weekly

You have full access to this open access article. To evaluate sleep quality in differentiated thyroid carcinoma DTC patients and correlate sleep disturbances with quality of life QoL. The same examinations were conducted in 53 subjects control group who had undergone surgery for benign thyroid pathology.

L-T4 dosages and TSH levels differed between the groups. BS and VAS scores were comparable. In disease-free DTC patients and subjects who undergo thyroid surgery for benign pathology, abnormal sleep components and insomnia are similar. The ThyPRO questionnaire closely reflects sleep disturbances in all subjects. Recognising and treating sleep disturbances might improve QoL. There is an association between thyroid function and sleep.

It is well known that the circadian rhythm and sleep-wake state can affect the secretion of TSH-thyroid hormones [ 1 , 2 , 3 ]. Patients with hyperthyroidism or hypothyroidism experience sleep disturbances, such as difficulty initiating and maintaining sleep, or reduced or even increased slow-wave sleep [ 4 , 5 ]. Subjects with sub-clinical hypothyroidism suffer more often from weakness and reduced muscle strength; this may result in insufficient strength for regular ventilation or the patency of upper airways [ 6 ], which are risk factors for sleep apnoea syndrome [ 7 ].

The hypothalamic—pituitary—thyroid axis is under the control of the supra-chiasmatic nucleus pacemaker [ 8 ]. Disruption of circadian rhythms has been recognised as a perturbation of the cell-cycle progression, and abnormal expression of circadian clock genes in differentiated thyroid cancer DTC has been suggested [ 8 ]. Several studies have documented poor sleep quality in patients with cancer, the incidence of sleep disturbance in oncologic patients being at least twice that found in the general population [ 9 , 10 , 11 , 12 , 13 ].

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