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Mapping the human genetic architecture of COVID-19

Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. Matters Arising to this article was published on 06 September Matters Arising to this article was published on 03 August The genetic make-up of an individual contributes to the susceptibility and response to viral infection.

Identifying host-specific genetic factors may reveal biological mechanisms of therapeutic relevance and clarify causal relationships of modifiable environmental risk factors for SARS-CoV-2 infection and outcomes.

Here we describe the results of three genome-wide association meta-analyses that consist of up to 49, patients with COVID from 46 studies across 19 countries. Several of these loci correspond to previously documented associations to lung or autoimmune and inflammatory diseases 3 , 4 , 5 , 6 , 7. They also represent potentially actionable mechanisms in response to infection.

Mendelian randomization analyses support a causal role for smoking and body-mass index for severe COVID although not for type II diabetes. The identification of novel host genetic factors associated with COVID was made possible by the community of human genetics researchers coming together to prioritize the sharing of data, results, resources and analytical frameworks.

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