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Slow gait speed and hyperglycemia were associated with cognitive dysfunction, mainly in the executive function domain, whereas IR was associated with memory impairment.

The participants with DM had lower general cognition and executive function. Our findings confirmed that IR, DM, sarcopenia, and cognitive dysfunction are mutually associated in complex ways. Understanding the mechanisms underlying these associations will lead to effective strategies to prevent and treat cognitive dysfunction in older individuals. Along with the increasingly aging populations in mainly developed countries, the number of individuals with cognitive impairment has grown, leading to increases in medical expenses as well as economic, physical, and psychological care-related burdens.

There are no curative treatments for cognitive dysfunction at this time, and the prevention of cognitive decline is a critical issue.