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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. The cause and effect relationship between serum uric acid levels and hypertension can be difficult to evaluate because antihypertensive drugs sometimes affect uric acid levels.

This cross-sectional study investigated the relationship between serum uric acid levels and hypertension in a general, healthy Japanese population who were not receiving medication for hyperuricemia or hypertension. The odds ratio OR of hypertension was 1. Compared with the lowest serum uric acid quartile, participants in the highest quartile had a 3. The results were similar for both systolic and diastolic hypertension. Elevated serum uric acid levels may be as important as obesity, dyslipidemia, diabetes, smoking and reduced kidney function for the development of hypertension and should be considered in hypertension prevention programs.

Hyperuricemia is frequently associated with lifestyle-related diseases. Although hyperuricemia is known to be correlated with cardiovascular events in hypertensive patients, 5 , 6 , 10 it remains unknown whether uric acid is an independent risk factor, a mediator or merely a marker for the development of HT.

Several recent small clinical trials have demonstrated that SUA-lowering agents such as allopurinol and probenecid can reduce blood pressure BP in adolescents, 15 , 16 suggesting that UA is an independent risk factor for the development of HT.