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You have full access to this open access article. No multidomain intervention trials have been designed for the prevention of cognitive decline in older adults with type 2 diabetes. To investigate the efficacy of a multidomain intervention in preventing cognitive decline in older adults with type 2 diabetes and cognitive impairment.

The multidomain intervention program includes management of metabolic and vascular risk factors, exercise, nutritional counseling, and promotion of social participation. Participants in the control group received usual care and treatment for type 2 diabetes. The primary outcome was the change in a composite score combining several neuropsychological tests from baseline to the month follow-up.

To assess the differences in cognitive changes between the intervention and control groups, a mixed-effects model for repeated measures was used. Finally, participants completed the trial. The between-group difference in the composite score changes was 0. Analyses for secondary outcomes indicated a positive impact of the intervention on memory and indicated that the intervention led to changes in dietary habits with increased intakes of niacin and meat, along with weight reduction compared to the control group.

The multidomain intervention did not demonstrate efficacy in preventing cognitive decline. However, this trial provided proof-of-concept evidence that multidomain interventions may offer cognitive benefits and contribute to changes in dietary behavior and weight reduction in older adults with type 2 diabetes and cognitive impairment. These findings should be confirmed in future studies. T ype 2 diabetes has become increasingly prevalent among older people worldwide 1.