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In this study, we investigated whether fetuses of women with milder hyperglycemia than GDM have accelerated abdominal growth, leading to adverse pregnancy outcomes. With fetal biometry data measured simultaneously with g GCT, relative fetal abdominal overgrowth was investigated by assessing the fetal abdominal overgrowth ratios FAORs of the ultrasonographically estimated gestational age GA of abdominal circumference AC per actual GA by the last menstruation period LMP , biparietal diameter BPD or femur length FL , respectively.
This is an open access article distributed under the terms of the Creative Commons Attribution License , which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. Data Availability: All relevant data are within the manuscript and its Supporting Information files. Competing interests: The authors have declared that no competing interests exist. The ACOG diagnostic criteria were originally designed to predict the development of type 2 diabetes mellitus T2DM in mothers post-pregnancy [ 3 ].
But controversy remains regarding the clinical risk of an isolated one-value abnormality OVA on the OGTT, with mixed results showing no risk [ 10 , 11 ] or an increased risk of adverse outcomes, such as large for gestational age LGA infants [ 12 ], macrosomia [ 13 ], cesarean section [ 14 ], and preeclampsia [ 15 ]. However, the clinical significance of this particular subject group has not been adequately addressed.
Investigating the clinical significance of OVA in pregnant women is thought to be important for the appropriate management of glucose intolerance during pregnancy. In our previous retrospective studies, we investigated fetal abdominal overgrowth indicative of abdominal obesity associated with maternal glucose intolerance. FAO persisted until delivery, even with appropriate treatment of GDM, leading to an increased risk of cesarean section, LGA infants and macrosomia [ 20 ].
