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Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Free full text in Europe PMC. We studied 90 healthy elders, who underwent lumbar puncture at baseline, and serial magnetic resonance imaging scans for up to 4 years.

The statistical effects in this exploratory study were mild and not significant after correction for multiple comparisons, but some of the identified proteins may be associated with brain atrophy in healthy people. The disease is believed to have a long pre-symptomatic phase with brain pathology accumulating prior to cognitive symptoms. The view that AD starts prior to any symptoms implies that its earliest changes can only be studied in people who are cognitively normal.

However, longitudinal studies on development of cognitive impairment in healthy people are limited by the long follow-up time and large study populations needed to detect significant cognitive changes. An alternative is to study longitudinal atrophy of AD-related brain regions, which are predictive of future cognitive decline Rusinek et al. Biomarkers predicting such atrophy in cognitively healthy people may be useful to identify persons at risk for AD, and could inform on biological mechanisms during early disease stages.

Jack et al. Our primary hypothesis was that baseline protein levels were associated with atrophy rates. We examined changes in gray matter volume in a priori specified regions of interest ROI in cognitively normal people. Structural magnetic resonance imaging brain scans at multiple time points up to 6 time points: ADNI screening, and 6, 12, 24, 36 and 48 months, median 5 scans per participant [range 2—6] were acquired at multiple sites using 1.