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The Guatemala syphilis experiments were United States -led human experiments conducted in Guatemala from to The experiments were led by physician John Charles Cutler , who also participated in the late stages of the Tuskegee syphilis experiment.

Doctors infected 1, people, including at least soldiers and people from various impoverished groups including, but not limited to, sex workers, orphans, inmates of mental hospitals, and prisoners with syphilis , gonorrhea , and chancroid , without the informed consent of the subjects.

Only of them received treatment. In total, 5, people were involved in all research experiments, of whom 83 died by the end of , though it is unknown whether or not the injections were responsible for all these deaths. However, the intentional infection of patients ended with the original study. On October 1, , the U. President, Secretary of State, and Secretary of Health and Human Services [ 2 ] formally apologized to Guatemala for the ethical violations. Guatemala condemned the experiment as a crime against humanity.

Multiple unsuccessful lawsuits have since been filed in the US. Professor Susan Mokotoff Reverby of Wellesley College uncovered information about these experiments in Cutler's archived papers in while researching the Tuskegee syphilis study.

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