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Thank you for visiting nature. You are using a browser version with limited support for CSS. To obtain the best experience, we recommend you use a more up to date browser or turn off compatibility mode in Internet Explorer. In the meantime, to ensure continued support, we are displaying the site without styles and JavaScript. It remains unclear whether caffeinated beverages could have deleterious renal effects in elderly population with underlying comorbid conditions. We assessed coffee, tea, and caffeine consumption from a validated food-frequency questionnaire and creatinine-based eGFR using the Chronic Kidney Disease Epidemiology Collaboration equation.

Multivariate-adjusted regression models were applied to test associations between baseline coffee, tea, or caffeine intake and 1-year eGFR changes. Similarly, individuals in the highest median, Decaffeinated coffee was not associated with eGFR changes.

Chronic kidney disease CKD poses a major public health challenge due to its detrimental impact on quality of life, increased morbidity and premature death, specifically in old people 1. Therefore, preserving renal function is essential to ensure the well-being and reduce adverse health outcomes in elders. Coffee and tea are rich in bioactive substances, such as phenolic compounds and minerals with antioxidant and anti-inflammatory properties, which can improve blood pressure, oxidative stress, dyslipidemia, and insulin resistance or hyperglycemia 8 , 9 , well-established risk factors for renal insufficiency.

There is evidence pointing to a protective effect of coffee and tea against type 2 diabetes, hypertension, and cardiovascular disease, conditions in which chronic inflammation plays a critical pathogenic role 10 , 11 , Nonetheless, there are potential side effects from caffeine contained in these beverages, even at moderate amounts, which may influence CKD-related cardiovascular outcomes and are of concern for the general population and especially for susceptible or at-risk individuals The results of epidemiological studies on coffee and tea consumption and kidney function have been inconsistent 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , Two recent meta-analyses, summarizing 7 cross-sectional studies on apparently healthy middle-aged adults, most from Asian countries, have concluded that coffee consumption is not associated with eGFR or CKD risk 6 , 7.