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Polioviruses, the prototypic enteroviruses, are the cause of paralytic poliomyelitis, a disease that has been well controlled by immunization in high- and middle-income countries and targeted for worldwide eradication.

The non-polio enteroviruses comprising the group A and B coxsackieviruses, echoviruses, and "newer" enteroviruses and the parechoviruses are responsible for a wide spectrum of disease in persons of all ages, although infection and illness disproportionately affect infants and young children.

The clinical manifestations, laboratory diagnosis, treatment, and prevention of non-polio enterovirus and parechovirus infections are reviewed in this topic. The virology, epidemiology, and pathogenesis of these infections are discussed separately. See "Enterovirus and parechovirus infections: Epidemiology and pathogenesis".

Poliovirus infection and prevention are discussed in detail elsewhere. See "Poliomyelitis and post-polio syndrome" and "Poliovirus vaccination". The terminology for the other serotypes in the original classification scheme remains unchanged eg, polioviruses, coxsackie A viruses, coxsackie B viruses, and echoviruses. See "Enterovirus and parechovirus infections: Epidemiology and pathogenesis", section on 'Classification'.