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Either your web browser doesn't support Javascript or it is currently turned off. In the latter case, please turn on Javascript support in your web browser and reload this page. Refer to the copyright information in the article for licensing details. Free full text in Europe PMC. Louis, Missouri, USA. Demographics, laboratory values, and clinical course were compared in children who did and did not receive COVIDdirected therapies.

Despite the lack of pediatric data evaluating treatments for COVID in critically ill children, more than half of children requiring intensive or high acuity care received COVIDdirected therapies.

Despite the occurrence of severe pediatric disease, few clinical treatment trials have included children [ 3 ], and the majority of treatment guidelines are geared toward adults [ 4 , 5 ]. Pediatric-specific recommendations regarding which patients should receive treatment and which therapeutics should be used rely on expert opinion based on data extrapolated from adult studies [ 6 , 7 ].

Although data on children are lacking, children were included in the emergency use authorizations EUA of some agents, including hydroxychloroquine and remdesivir [ 10 , 11 ].